Laboratory of Structural Biology
We study the cellular mechanisms that maintain DNA integrity and prevent genomic instability, and we have a particular interest in the family of enzyme known as poly(ADP-ribose) polymerases, or PARPs.
We use biochemistry, cell biology, and the powerful tools of structural biology (i.e. X-ray crystallography, small-angle x-ray scattering, and electron microscopy) to address fundamental biological questions.
