Laboratory of Structural Biology
We are an academic research group in the Department of Biochemistry and Molecular Medicine at Université de Montréal (UdeM).
We study the cellular mechanisms that maintain DNA integrity and prevent genomic instability, and we have a particular interest in the family of enzyme known as poly(ADP-ribose) polymerases, or PARPs.
We use biochemistry, cell biology, and the powerful tools of structural biology (i.e. X-ray crystallography, small-angle x-ray scattering, and electron microscopy) to address fundamental biological questions.
Human PARP-1 signaling DNA damage
